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KMID : 0358420120550030143
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Korean Journal of Obstetrics and Gynecology
2012 Volume.55 No. 3 p.143 ~ p.147
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Pharmacotherapy for premenstrual dysphoric disorder: A meta-analysis of phase 3 trials
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Yum Sun-Kyoung
Ryu Min-Ji
Park Na-Yoon
Kim Seong-Min
Yi Kyong-Wook
Park Hyun-Tae
Shin Jung-Ho
Hur Jun-Young
Kim Sun-Haeng
Kim Tak
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Abstract
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Premenstrual dysphoric disorder (PMDD) is a common condition that temporarily, but repetitively affects patient’s global function. Patients and physicians alike are often uncertain whether prescription medication for PMDD is sufficiently effective. The primary objective of this analysis is signal detection in efficacy of pharmacological treatments in PMDD. Secondary objective is to review which symptoms are likely to respond to which medications. The review included otherwise healthy women with clinician confirmed diagnosis of PMDD who participated in phase 3 clinical trials for the treatment of PMDD. Twelve pair-wise comparisons of drug and placebo for 2,420 patients with PMDD were performed. Oral contraceptives and selective serotonin receptor inhibitor were effective in alleviating symptoms of PMDD compared to placebo. Both Intermittent and continuous administration were more effective than placebo. This meta-analysis provides a signal that pharmacological treatment of PMDD is effective.
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KEYWORD
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Premenstrual syndrome, Drug therapy, Meta-analysis, Clinical trial, phase 3
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